Cocaine Mass Concentration in Serum/Plasma (24-hour Urine)

Why This Test Is Done

Doctors may order this test if you have symptoms like anxiety, rapid heartbeat, or trouble sleeping that could be linked to cocaine use. It’s also used in medical settings to screen for substance use in patients, especially those undergoing treatment or evaluation for addiction. Some employers or legal systems may request it as part of a broader drug screening process.

What to Expect Before the Test

You’ll typically provide a urine sample in a private area of the lab or clinic. No special preparation is needed, but you may be asked to avoid certain medications or substances that could interfere with results. If you’re pregnant, breastfeeding, or have a medical condition, let your provider know before testing.

What the Test Results Mean

Results are reported as the total mass of cocaine and its metabolites in your urine. A positive result indicates recent cocaine use, but it doesn’t confirm the exact amount or timing of exposure. False positives can occur with certain medications or other substances, so follow-up testing may be needed for unclear results.

Common Causes of Abnormal Results

Elevated levels of cocaine or its metabolites in urine can be due to recent cocaine use, but other factors like certain medications (e.g., some antidepressants or painkillers), illegal drugs (e.g., amphetamines), or even exposure to secondhand smoke may also produce false positives. If you’re unsure about your results, discuss them with your healthcare provider.