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Serum Antibody to *Coccidioides* (Qualitative, Immunoassay)

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies in your blood that may indicate exposure to *Coccidioides*, a fungus found in certain desert regions. It helps assess risk for infection, especially if you’ve traveled to or live in areas where the fungus is common.

Quick summary

["This screening test helps identify possible exposure to a fungal infection that can affect the lungs and other body systems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49712-3
Short code
Coccidioides Ab Ser Ql LA
Synonyms
Coccidioides Ab Ser Ql LA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
la
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test looks for antibodies produced by your immune system in response to *Coccidioides* exposure. Antibodies are proteins that can signal whether your body has encountered the fungus, though they may not always mean you have an active infection.

Why Might You Need This Test?

You may be tested for *Coccidioides* antibodies if you’ve lived or traveled in areas like the southwestern U.S., parts of Mexico, or certain regions of South America, South Africa, or Australia. Doctors may also recommend it if you have symptoms like coughing, fever, or fatigue, or if you have a weakened immune system.

What Are Common Symptoms?

If you have an active infection, symptoms can range from mild (like a cold) to severe (such as chest pain, skin rashes, or joint pain). Many people don’t show symptoms at all, but the test can still help track exposure risk.

How Is the Test Done?

A blood sample is taken from a vein in your arm. The sample is sent to a lab where antibodies to *Coccidioides* are tested using an immunoassay method. Results are qualitative (positive or negative) rather than a specific number.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

A positive result suggests possible exposure to *Coccidioides*, but it doesn’t always mean you have an active infection. Some people may develop antibodies years after exposure. If you’re at higher risk (e.g., pregnant, immunocompromised), follow-up testing or medical evaluation may be needed to assess further.

Short name

Coccidioides antibody screen

Frequently asked questions

What Does a Positive Result Mean?
A positive result means your blood contains antibodies against *Coccidioides*, indicating past or possible exposure. It doesn’t confirm an active infection but may prompt additional testing or medical advice, especially if you live in or traveled to high-risk areas.
What Does a Negative Result Mean?
A negative result means your blood did not detect antibodies to *Coccidioides* at the time of testing. However, exposure could have occurred earlier, so repeated testing may be needed if you have risk factors.
How Often Should I Get Retested?
If you’ve been exposed to *Coccidioides* and test negative, your doctor may recommend retesting if symptoms develop or if you have ongoing risk factors (e.g., travel to high-risk areas). There’s no standard schedule, so follow your healthcare provider’s guidance.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy