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Serum or Plasma Creatinine Concentration (Mass Concentration)

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of creatinine, a waste product from muscle metabolism, in your blood or plasma. It helps assess how well your kidneys are filtering blood.

Quick summary

["A creatinine test helps check kidney function and detect early kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
7239-7
Short code
Cocklebur BasoBnd Ab Qn
Synonyms
Cocklebur BasoBnd Ab Qn
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
22
Ref high
198
Critical range
— – 10000 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
lhr
CPT
82553
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Matters

Creatinine is a byproduct of muscle breakdown that your kidneys filter out of your blood. High levels may indicate reduced kidney function, while low levels could suggest dehydration or muscle loss. This test is often used alongside other kidney function tests to monitor conditions like chronic kidney disease or kidney damage from medications or illnesses.

How the Test Works

Your blood or plasma sample is sent to a lab where it is analyzed using a specialized method, often an enzymatic or automated chemical assay. The lab measures how much creatinine is present and compares it to a standard reference range.

What to Expect Before the Test

You may have this test done while you’re at the doctor’s office, a clinic, or a lab. No special preparation is usually needed, but you might be asked to fast for a few hours if it’s part of a larger blood panel. Drink plenty of water the day before if you’re concerned about dehydration.

What to Expect During the Test

The test involves drawing a small amount of blood from a vein, typically in your arm. You may feel a slight pinch, but it usually doesn’t cause significant discomfort. The process takes a few minutes, and you can return to your normal activities afterward.

Reference range

Adult males: 22-198 U/L; Females: 22-198 U/LN/A

Specimen: whole-blood

No special preparation required. Inform provider of any chest pain or symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

High creatinine levels can signal kidney problems, including chronic kidney disease, acute kidney injury, or conditions that affect blood flow to the kidneys (like heart failure or severe dehydration). Low levels may suggest dehydration, low muscle mass, or liver disease. Doctors use creatinine levels to monitor kidney function over time, adjust medications, and guide treatment plans for conditions like diabetes or high blood pressure.

Short name

Creatinine

Frequently asked questions

How often should I get this test?
The frequency depends on your health condition. If you have kidney disease, diabetes, or high blood pressure, your doctor may recommend regular testing. Otherwise, it’s often checked once or twice a year if you’re at higher risk or undergoing certain treatments.
Can diet or exercise affect my creatinine levels?
Dietary protein intake can influence creatinine levels, as muscle breakdown produces creatinine. Eating a balanced diet with moderate protein is usually fine, but very high protein diets may temporarily raise levels. Exercise itself doesn’t directly change creatinine levels, but it can affect hydration and muscle use.
What if my results are outside the normal range?
If your creatinine levels are higher than expected, your doctor may investigate further to check for kidney issues or other health problems. If they’re lower, they might look into dehydration, muscle loss, or other factors. Your doctor will discuss the results with you and recommend next steps, such as additional tests or lifestyle changes.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy