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Total IgE (Immunoglobulin E) Antibody Level

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of Immunoglobulin E (IgE) in your blood. IgE is a type of antibody that plays a role in allergic reactions and responses to parasites.

Quick summary

["IgE levels can help identify allergies or immune system responses."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
61326-5
Short code
Cocklebur IgE/IgE total %
Synonyms
Cocklebur IgE/IgE total %
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
22
Ref high
198
Critical range
— – 10000 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82553
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like sneezing, itching, rash, or breathing difficulties that suggest allergies. It could also be used to check for conditions like asthma, eczema, or parasitic infections, or to monitor immune responses in certain treatments.

What to Expect During the Test

A small amount of blood will be drawn from a vein in your arm. You may feel a slight pinch, but it usually doesn’t cause much discomfort. The blood sample is then sent to a lab for analysis.

What the Results Mean

IgE levels can vary widely among individuals. High levels may indicate allergies, asthma, or other allergic conditions. Very low levels might suggest a weakened immune response to certain allergens. Your healthcare provider will discuss the results in the context of your symptoms and medical history.

Preparation and Care

No special preparation is usually needed for this test. However, if you are on certain medications or have specific health conditions, let your healthcare provider know before the test.

Reference range

Adult males: 22-198 U/L; Females: 22-198 U/LN/A

Specimen: serum

No special preparation required. Inform provider of any chest pain or symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated IgE levels are commonly associated with allergic reactions, including hay fever, food allergies, and allergic asthma. They can also be linked to parasitic infections or certain autoimmune conditions. Low IgE levels may be seen in individuals with a reduced allergic response or certain immune deficiencies. This test helps guide treatment plans for allergies, asthma management, and other immune-related conditions.

Short name

IgE Total

Frequently asked questions

What causes elevated IgE levels?
Elevated IgE levels are often linked to allergic reactions, such as to pollen, dust mites, pet dander, or certain foods. They can also be associated with parasitic infections or conditions like asthma and eczema. Sometimes, IgE levels can be elevated due to certain medications or immune system disorders.
What does it mean if my IgE levels are high?
High IgE levels typically suggest an overactive immune response to allergens or other triggers. Your healthcare provider may recommend allergy testing or other treatments to manage symptoms, such as avoiding known allergens, using antihistamines, or receiving allergy immunotherapy (allergy shots).
Can IgE levels be affected by medications?
Yes, some medications, like certain antibiotics, steroids, or antihistamines, can temporarily affect IgE levels. It’s important to inform your healthcare provider about all medications you are taking before the test, as this can influence results and interpretation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy