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C-reactive protein (high-sensitivity) in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that rises when your body is fighting inflammation, often used to check for subtle signs of inflammation or infection.

Quick summary

["hs-CRP helps track low-level inflammation that may not show up in other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
74670-1
Short code
Coc+Met Sal Ql Cfm
Synonyms
Coc+Met Sal Ql Cfm
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
confirm
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to monitor chronic conditions like heart disease, arthritis, or autoimmune disorders, or to check for early signs of infection or inflammation after surgery or injury. It can also help assess risk for future health issues like heart attacks or strokes.

What Does a High or Low Result Mean?

A higher-than-normal hs-CRP level suggests increased inflammation, which may signal conditions like heart disease, certain infections, or inflammatory diseases. A very low level may indicate no active inflammation, but it doesn’t rule out other health concerns. Results are interpreted by your provider based on your overall health.

How Is the Test Performed?

A small blood sample is drawn from your arm, usually in a doctor’s office or lab. The blood is sent to a lab where it’s analyzed to measure the hs-CRP protein levels.

What Should You Do Before the Test?

No special preparation is needed, but inform your provider if you’re taking blood thinners, have recently had an infection, or are pregnant. Avoid strenuous exercise or heavy meals 24 hours before the test if advised by your provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: hs-CRP’s Role in Health Monitoring

Short name

hs-CRP

Frequently asked questions

What are the normal results?
Normal results vary by lab and individual health status. A low hs-CRP level (typically below 1 mg/L) suggests minimal inflammation, while higher levels (above 3 mg/L) may indicate increased cardiovascular risk or active inflammation. Your provider will discuss results in the context of your medical history.
How often should I get this test?
Your provider will determine how often to check your hs-CRP based on your health needs. Some people with chronic conditions may get it yearly or more often, while others may only need it occasionally.
Can lifestyle changes affect hs-CRP levels?
Yes! Regular exercise, a heart-healthy diet, and managing stress can lower inflammation and potentially reduce hs-CRP levels. Smoking, obesity, and poor diet may raise it, so small changes can make a difference over time.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy