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Urine Codeine Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of codeine, a pain-relieving opioid, in your urine over a 24-hour period. It helps assess drug exposure, monitor treatment, or detect recent use.

Quick summary

["This test helps track opioid levels in your body over time for medical or legal purposes."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
51739-1
Short code
Codeine Free Ur-mCnc
Synonyms
Codeine Free Ur-mCnc
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test if you’re taking codeine for pain relief, undergoing treatment for opioid dependence, or if there’s suspicion of codeine use—such as in workplace drug testing, legal investigations, or evaluating side effects.

What to Expect Before the Test

No special preparation is needed. You’ll provide a 24-hour urine sample collected from the time you wake up in the morning until the same time the next day. Follow your doctor’s instructions for proper collection to ensure accuracy.

How the Test Works

Your urine is analyzed using a sensitive laboratory method (likely high-performance liquid chromatography or immunoassay) to measure codeine’s concentration. The test detects the opioid’s presence and quantifies how much was excreted in your urine.

What the Results Mean

Results are reported as the total mass of codeine in your urine over 24 hours. Higher levels may indicate recent use, higher tolerance, or potential misuse. Your doctor will interpret results in the context of your medical history and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Urine Codeine (24-hour)

Frequently asked questions

How often should I get this test?
This test is typically done as needed—such as during treatment for opioid dependence, before surgery, or in cases of suspected misuse. Your doctor will determine the frequency based on your situation.
What if my results are abnormal?
Abnormal results may trigger further evaluation, such as additional tests or discussions about your medication use. Your doctor will explain next steps based on your specific situation.
Can I drink alcohol before this test?
Alcohol itself doesn’t interfere with this test, but it’s best to avoid it if you’re also taking codeine, as mixing them can increase side effects like drowsiness or dizziness. Always follow your doctor’s advice.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy