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C-reactive protein (high-sensitivity) in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein produced by your liver in response to inflammation, helping assess low-grade inflammation or risk for conditions like heart disease.

Quick summary

["hs-CRP helps track inflammation, a key factor in many chronic health issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
6721-5
Short code
Codfish IgG Qn
Synonyms
Codfish IgG Qn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order hs-CRP to monitor chronic conditions like heart disease, arthritis, or diabetes, or to check for signs of inflammation after surgery, injury, or infection. It can also help evaluate risk for future health problems.

What Does a Result Mean?

Results are not given in absolute numbers but are compared to general reference ranges. Higher levels may indicate inflammation, while lower levels suggest reduced inflammation. Your doctor will interpret results in the context of your health history.

How Is the Test Performed?

A blood sample is taken from a vein, usually in your arm. The sample is sent to a lab where it is analyzed using a sensitive immunoassay method to detect the protein.

Common Causes of Abnormal Results

Elevated hs-CRP can be caused by infections, autoimmune diseases, obesity, smoking, or certain medications. Low levels may occur with very low inflammation or certain medical treatments.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

hs-CRP

Frequently asked questions

What does my hs-CRP level tell me about my health?
Your hs-CRP level helps your doctor assess inflammation-related risks. For example, higher levels may signal a need for lifestyle changes or closer monitoring of conditions like heart disease or diabetes. Always discuss your results with your healthcare provider for personalized advice.
Can I lower my hs-CRP level?
Yes, lifestyle changes such as improving diet, increasing physical activity, quitting smoking, and managing stress can help reduce inflammation and lower hs-CRP levels. Your doctor may also recommend specific treatments if inflammation is linked to a diagnosed condition.
How often should I get this test?
Your doctor will determine the frequency based on your health needs. Some patients get it annually or more often if they have chronic conditions requiring monitoring. Follow their guidance to ensure proper care.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy