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C-reactive protein (high-sensitivity) in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein produced by the liver in response to inflammation, helping assess your body’s inflammatory state.

Quick summary

["hs-CRP helps track inflammation, which may signal underlying conditions like infections, autoimmune diseases, or heart disease risk."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
71888-2
Short code
COHgb MFr.DF BldC
Synonyms
COHgb MFr.DF BldC
Category
hematology
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
12
Ref high
17.5
Critical range
7 N/A – 20 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85018
SNOMED
900000000000003004
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order hs-CRP to monitor chronic conditions (e.g., rheumatoid arthritis), evaluate risk for heart disease, or check for signs of infection or inflammation after surgery or injury.

What Does a Result Mean?

Results are not given in absolute numbers, but they’re used relative to your health status. Higher levels may indicate more inflammation, while lower levels suggest reduced inflammation.

Common Uses in Care

Commonly used alongside other tests to guide treatment plans, such as managing arthritis symptoms or planning preventive care for cardiovascular health.

How Is the Sample Collected?

A blood sample is drawn from a vein, usually in your arm. The blood is separated into serum or plasma for testing.

Reference range

Adult males: 13.5-17.5 g/dL; Females: 12.0-16.0 g/dLN/A

Specimen: whole-blood

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

hs-CRP

Frequently asked questions

hs-CRP is a marker of systemic inflammation. Elevated levels may signal conditions like cardiovascular disease, infections, or autoimmune disorders, but it’s not definitive on its own.
hs-CRP results are often interpreted alongside other clinical findings, such as symptoms, medical history, and other lab tests.
What can affect my hs-CRP levels?
Factors like recent illness, infection, stress, smoking, or certain medications can temporarily raise hs-CRP levels. Avoiding these influences before testing may improve accuracy.
How often should I get this test?
Your doctor will determine the frequency based on your health needs, such as monitoring chronic conditions or assessing risk factors for heart disease.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy