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Serum or Plasma Alpha-1 Antitrypsin (A1AT) Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs from damage caused by enzymes released during inflammation.

Quick summary

["Alpha-1 Antitrypsin helps prevent lung disease and can be checked if you have a family history of lung or liver problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
7246-2
Short code
Cola Nut BasoBnd Ab Qn
Synonyms
Cola Nut BasoBnd Ab Qn
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
lhr
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like chronic cough, shortness of breath, or liver issues. It’s also used to screen for genetic conditions that affect Alpha-1 Antitrypsin levels, especially in people with a family history of lung diseases like emphysema or chronic obstructive pulmonary disease (COPD).

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm or a blood sample may be collected from a finger prick. If plasma is used, it’s drawn from a vein. Avoid smoking or heavy exercise 24 hours before the test if instructed.

What the Results Mean

Lower than normal levels may indicate a genetic disorder (like Alpha-1 Antitrypsin Deficiency), while higher levels could be due to liver disease or other conditions. Your doctor will interpret results in the context of your symptoms and medical history.

Common Causes of Abnormal Results

Low levels: Genetic mutation, liver disease, smoking, or chronic lung conditions. High levels: Liver disease, certain medications, or rare genetic conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Alpha-1 Antitrypsin Level

Frequently asked questions

What does a low Alpha-1 Antitrypsin level suggest?
A low level may indicate Alpha-1 Antitrypsin Deficiency, a condition that increases the risk of lung diseases like emphysema or liver cirrhosis. Early diagnosis can help manage symptoms and prevent complications.
How does this test differ from a general protein panel?
This test specifically measures Alpha-1 Antitrypsin, a single protein, while a general protein panel checks multiple proteins (like albumin, globulins) in your blood. Alpha-1 Antitrypsin is key for lung protection and is often tested separately for genetic screening.
Can diet affect Alpha-1 Antitrypsin levels?
Diet alone typically doesn’t change Alpha-1 Antitrypsin levels, but certain foods (like those high in sulfur-containing amino acids) may indirectly affect liver function that produces this protein. Always follow your doctor’s advice for dietary changes related to your test results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy