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Colistin Resistance Microbial Culture and Susceptibility Test (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks whether bacteria in your body may be resistant to colistin, a type of antibiotic used to treat serious infections caused by certain bacteria.

Quick summary

["Helps determine if your infection could be harder to treat with standard antibiotics."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
86221-9
Short code
Colistin res mcr-1 Islt/Spm Ql
Synonyms
Colistin res mcr-1 Islt/Spm Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
CPT
85610
SNOMED
396252006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

This test involves growing bacteria from a sample (likely blood or other body fluid) and testing their response to colistin. Resistance means the bacteria survive exposure to colistin, which could indicate a need for alternative treatments.

Why It’s Ordered

Your healthcare provider may order this test if you have a severe infection with bacteria that are known to be resistant to colistin or if you’ve been exposed to colistin-resistant bacteria.

What to Expect

The test involves taking a sample (e.g., blood or urine) and sending it to a lab. Results are typically available within 2–5 business days. You may not need to prepare for this test.

Possible Outcomes

If the test shows resistance, it means the bacteria in your sample may not respond to colistin. This can guide treatment choices, such as switching to a different antibiotic.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: serum

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Colistin resistance is critical because it limits treatment options for infections caused by multidrug-resistant (MDR) bacteria. Early identification helps prevent spread and ensures appropriate antibiotic use to preserve effectiveness.

Short name

Colistin Resistance Screening

Frequently asked questions

What does a positive result mean?
A positive result means the bacteria in your sample may be resistant to colistin, which could affect how your infection is treated. Your doctor will discuss next steps based on the result and your clinical picture.
How long does it take to get results?
Results are usually available within 2 to 5 business days, depending on lab processing times. Your doctor will contact you once results are ready.
Can I take antibiotics before this test?
It’s important to follow your doctor’s instructions regarding any antibiotics. Taking antibiotics before the test may affect the accuracy of the result. Do not stop any prescribed medication without consulting your provider first.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy