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Colorectal Cancer Stool DNA Screening (Fecal DNA Analysis)

Published: August 9, 2026Updated: August 16, 2026

This test checks for DNA changes in your stool that may indicate colorectal cancer or precancerous polyps. It’s a non-invasive way to help detect early signs of the disease.

Quick summary

["A simple stool test that may help find colorectal cancer early, often before symptoms appear."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
100227-8
Short code
Colon capsule endo study Doc
Synonyms
Colon capsule endo study Doc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

How the Test Works

Your stool sample is analyzed for specific DNA markers that can be altered in colorectal cancer or precancerous growths. This test looks for genetic changes that aren’t present in healthy cells.

What to Expect Before the Test

You’ll collect a small sample of stool using a provided kit. No special preparation is needed, but avoid taking certain medications (like blood thinners) that might affect results. Bring the sample to your doctor’s office or lab within the specified timeframe.

What the Results Mean

If the test is positive, it means your sample contains DNA changes that may suggest colorectal cancer or precancerous polyps. Further testing (like a colonoscopy) will be needed to confirm the diagnosis. A negative result means no obvious DNA changes were found, but it doesn’t guarantee you’re cancer-free.

When You Might Need This Test

This screening is often recommended for adults starting at age 45 (or earlier, depending on family history or other risk factors). It’s also used as part of follow-up for people who have had abnormal colonoscopy results or have a higher risk of colorectal cancer.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Colorectal Cancer Screening

Frequently asked questions

Why is this test important?
Colorectal cancer is often detected early when it’s easier to treat. This test helps catch potential issues before they become serious, giving you more treatment options and improving outcomes. Early detection can save lives and reduce the need for more invasive procedures.
What does a positive result mean?
A positive result means your doctor will likely recommend further testing, such as a colonoscopy, to investigate further. This is because the DNA changes found in the stool test can sometimes appear in both cancer and precancerous polyps, so more detailed testing is needed to confirm the cause.
Can this test replace a colonoscopy?
No, this test is a screening tool and isn’t a replacement for a colonoscopy. A colonoscopy is the gold standard for diagnosing colorectal cancer and removing polyps, but this stool test can help identify people who need further evaluation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy