Skip to content

Combined Immunodeficiency Multigene Analysis (Whole Blood DNA)

Published: August 9, 2026Updated: August 16, 2026

This test examines genetic variations across multiple genes linked to primary immunodeficiency disorders, helping identify potential causes of weakened immune function.

Quick summary

["A genetic check for rare immune system disorders that may affect your health or increase infection risk."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
112329-8
Short code
Combined immunodeficiency multigene analysis Bld/T
Synonyms
Combined immunodeficiency multigene analysis Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
CPT
86038
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What This Test Measures

The test analyzes DNA from your blood to detect specific mutations in genes associated with primary immunodeficiencies. These mutations can impair immune cell development or function, leading to recurrent infections, chronic inflammation, or other immune-related symptoms. Some genes may also be linked to autoimmune conditions or cancer risk.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like frequent, severe infections (e.g., pneumonia, sinusitis, or skin infections), unusual allergic reactions, or a family history of immunodeficiency. It’s also used in newborn screening programs or for diagnosing suspected inherited immune disorders.

Sample Collection and Process

A blood sample is drawn from your arm, and DNA is extracted from your white blood cells. The lab then sequences DNA from multiple genes to identify any inherited changes that could affect immunity. Results are compared to a reference database of known genetic variations.

What to Expect After Testing

Results typically take 4–8 weeks. If abnormalities are found, your doctor will discuss next steps, which may include additional testing, monitoring, or genetic counseling. Follow-up may involve managing symptoms, lifestyle adjustments, or specialized treatments if applicable.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Multigene Panel for Immunodeficiency

Frequently asked questions

How can I prepare for this test?
No special preparation is needed. You may eat and drink normally on the day of your blood draw, but inform your doctor if you’re taking medications that could affect blood clotting (e.g., blood thinners).
What does a positive result mean?
A positive result indicates genetic variants in one or more immunodeficiency-related genes. These variants may explain your immune symptoms or increase your risk of infections, but they don’t always cause symptoms. Your doctor will interpret results in the context of your medical history and symptoms.
Will this test affect my insurance or coverage?
Coverage depends on your insurance plan and clinical indication. Some insurers may require prior authorization for genetic testing. Always confirm with your provider or insurance company before the test to understand costs and coverage details.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy