Skip to content

Complexed Serum Protein (e.g., Calcium Binding Protein) Measurement

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood that is bound to calcium, which can help assess how well calcium is being managed in your body. This may relate to conditions affecting protein binding or calcium metabolism.

Quick summary

["Understanding your protein-calcium binding levels can help identify potential issues with calcium regulation or protein function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
33667-7
Short code
Complexed PSA SerPl-mCnc
Synonyms
Complexed PSA SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
4
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84153
SNOMED
39392002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test if you have symptoms like muscle weakness, bone pain, or abnormal calcium levels. It could also be part of a broader evaluation for conditions such as kidney disease, liver problems, or metabolic disorders affecting protein binding.

What to Expect Before the Test

No special preparation is typically required. You may need to fast for 8–12 hours before the test if it involves a blood draw, but confirm with your provider. Avoid strenuous activity the day before.

How the Test Is Performed

A blood sample will be taken from a vein in your arm. The blood is processed to separate serum (or plasma), where the protein is measured using a specialized lab technique to detect its calcium-binding capacity.

What the Results Mean

Results are compared to a reference range for your age, sex, and overall health. Abnormally high or low levels may signal issues like protein dysfunction, kidney disease, or hormonal imbalances affecting calcium binding.

Reference range

Normal: <4.0 ng/mLN/A

Specimen: serum

No special preparation required. For PSA, avoid sexual activity for 24-48 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Complexed Protein Level

Frequently asked questions

What causes abnormal complexed protein levels?
Abnormal results could be due to kidney disease, liver dysfunction, severe dehydration, or certain medications that affect protein synthesis or calcium binding. Chronic illnesses like diabetes or autoimmune disorders may also influence these levels.
How often should I get this test?
Your provider will determine the frequency based on your health status, symptoms, and any ongoing conditions. Regular monitoring may be needed if you have a history of kidney disease, liver issues, or metabolic disorders.
Can diet affect this test result?
Dietary factors like high protein intake or certain supplements (e.g., calcium or vitamin D) may indirectly influence protein binding. Avoiding excessive salt or protein-rich foods for a few days before testing can help stabilize results, but confirm with your provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy