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Albumin to Globulin Ratio (A/G Ratio) – Serum

Published: August 9, 2026Updated: August 17, 2026

This test compares the levels of albumin and globulin proteins in your blood to help assess your overall protein balance and potential nutritional or liver health issues.

Quick summary

["A/G ratio helps identify protein imbalances that may signal underlying health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
103062-6
Short code
Conalb (nGal d) 3 IgE RAST
Synonyms
Conalb (nGal d) 3 IgE RAST
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
40
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
rast
CPT
84484
SNOMED
302774002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Albumin and Globulin Are

Albumin is a protein produced by your liver that helps maintain fluid balance in your blood. Globulin includes a variety of proteins that support immune function, blood clotting, and transport of substances like hormones and metals. Your blood sample is tested for both protein types to calculate the ratio.

Why This Test Is Done

Doctors may order an A/G ratio to evaluate conditions like malnutrition, liver disease, chronic kidney disease, or certain immune disorders. It can also help monitor treatment responses for conditions affecting protein levels.

How the Test Works

A small blood sample is drawn and analyzed to measure albumin and globulin concentrations. The results are then used to calculate the ratio, which provides insight into protein status without needing individual reference ranges for each protein alone.

What the Results Mean

An elevated A/G ratio may suggest conditions like chronic liver disease or malnutrition, where albumin levels drop while globulin levels rise. A low ratio could indicate severe malnutrition or liver dysfunction. Your doctor will interpret results in the context of your overall health.

Reference range

Adult: 10-40 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

A/G Ratio

Frequently asked questions

What causes might lead to an abnormal A/G ratio?
Abnormal A/G ratios can result from liver disease (reducing albumin production), chronic kidney disease (affecting protein metabolism), malnutrition (low protein intake), or certain immune disorders (increasing globulin production). Your doctor may also check for conditions like cirrhosis, hepatitis, or protein-losing syndromes.
How often should I get this test?
The frequency depends on your health status. If you have a known condition like liver disease or malnutrition, your doctor may recommend regular monitoring. Otherwise, this test is often part of routine checkups or when symptoms suggest protein imbalance.
Can diet affect A/G ratio results?
Yes, diet plays a role. High-protein diets or nutritional deficiencies can influence albumin levels, while certain foods or supplements may impact globulin production. Always follow your doctor’s advice regarding dietary changes before or after testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy