Skip to content

Total Protein (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes albumin and other proteins like globulins.

Quick summary

["Total protein helps assess overall protein balance and potential liver or kidney issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
71496-4
Short code
CORPORATEORGANIZATIONCODE
Synonyms
—
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
esrd
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to check for conditions affecting protein production, such as liver disease, kidney problems, malnutrition, or certain immune disorders. It can also help monitor treatment responses or diagnose conditions like edema (fluid retention) or dehydration.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if it’s part of a broader metabolic panel. Bring any medications you’re taking to your appointment.

How the Test Works

A blood sample is drawn from a vein, typically in your arm. The blood is sent to a lab where it’s analyzed to measure the total protein concentration in your serum.

What the Results Mean

Results are compared to standard ranges, though exact values can vary by lab. Low protein levels may indicate malnutrition, liver disease, or kidney problems, while high levels could suggest dehydration, inflammation, or certain cancers.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Protein

Frequently asked questions

What causes abnormal protein levels?
Abnormal protein levels can stem from conditions like chronic liver disease, kidney failure, severe infections, or malnutrition. High protein levels may also occur with dehydration or certain inflammatory states.
How often should I get this test?
Your doctor will determine frequency based on your health needs—this may include routine checks, monitoring chronic conditions, or follow-ups after treatment.
Can diet affect protein test results?
Yes, diet can influence protein levels. High-protein diets or certain foods (like gluten-containing grains) may temporarily alter results, so avoid major dietary changes before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy