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Cortisol, 15-Metabolite (Free Cortisol Metabolite Profile) – Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the breakdown products of cortisol, a hormone produced by your adrenal glands. It helps assess how well your body processes cortisol over time.

Quick summary

["This test may help identify issues with cortisol metabolism that could affect your energy, stress response, or overall health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
102025-4
Short code
Cortis 1.5h p Gc SerPl-mCnc
Synonyms
Cortis 1.5h p Gc SerPl-mCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like fatigue, unexplained weight changes, or signs of hormonal imbalances. It could also be used in research or specialized evaluations for conditions linked to cortisol metabolism.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before drawing blood. Avoid caffeine or alcohol for 24 hours prior. Let your provider know about any medications you’re taking.

What Happens During the Test

A healthcare professional will draw blood from a vein in your arm. You may feel a slight pinch, but it usually doesn’t cause discomfort. The blood sample is sent to a lab for analysis.

What the Results Mean

Results provide detailed information about cortisol’s breakdown products, helping identify patterns in metabolism. Your provider will interpret these results in the context of your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cortisol Metabolite Test

Frequently asked questions

How long does it take to get my results?
Results are typically available within 1–3 business days, depending on lab processing times. Your provider will contact you once they’re ready.
Can I eat or drink anything before this test?
Yes, you can eat normally, but avoid caffeine or alcohol for 24 hours before your blood draw. Follow your provider’s specific instructions for fasting if required.
What does this test replace or complement?
This test complements standard cortisol measurements by offering a broader view of cortisol’s metabolic breakdown. It may be used alongside other tests, such as cortisol levels or cortisol-binding protein studies, depending on clinical needs.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy