Cortisol, Serum (Early Morning, 8 AM)

Why This Test Is Done

Your doctor may order this test to evaluate conditions affecting your adrenal glands, such as Cushing’s syndrome (overproduction of cortisol) or Addison’s disease (underproduction of cortisol). It can also help diagnose adrenal insufficiency, stress-related hormonal imbalances, or rule out other causes of fatigue, weight changes, or unexplained symptoms like high blood pressure or muscle weakness.

What to Expect Before the Test

No special preparation is needed for this test. You’ll have a small needle inserted into your arm to draw blood. The process takes a few minutes, and you can resume normal activities afterward. If you’re taking medications that affect cortisol levels, let your healthcare provider know.

What the Results Mean

Cortisol levels fluctuate naturally throughout the day, with the highest levels typically occurring in the early morning. Abnormally high or low levels can signal underlying health issues. Your doctor will interpret the results in the context of your symptoms and medical history.

Common Conditions Linked to Cortisol Testing

High cortisol levels may be linked to conditions like Cushing’s syndrome, chronic stress, or certain tumors. Low cortisol levels can indicate adrenal insufficiency, autoimmune disorders, or long-term steroid use. Your doctor will guide you on next steps based on the findings.