Cortisol (Mass Concentration) in Saliva

Why This Test Is Done

Your healthcare provider may order this test to evaluate chronic stress, adrenal gland function, or to monitor conditions like Cushing’s syndrome or Addison’s disease. It can also help diagnose or manage conditions affecting cortisol levels, such as depression or anxiety.

A small saliva sample is collected, typically in the morning when cortisol levels are naturally highest. The sample is then analyzed to determine cortisol concentration.

No special preparation is needed, but you may be advised to avoid caffeine or smoking for a few hours before collection to ensure accurate results. Avoid brushing your teeth right before sampling to prevent interference.

Results are not provided with specific reference ranges, as they depend on clinical context. Elevated levels may indicate chronic stress or adrenal dysfunction, while very low levels could suggest hormonal imbalances.

Elevated cortisol levels might suggest conditions like Cushing’s syndrome or excessive stress responses, while persistently low levels could indicate adrenal insufficiency or other hormonal disorders.

Common Conditions Monitored

This test is often used to monitor stress-related conditions, such as chronic stress, anxiety, or depression. It may also be part of a broader evaluation for hormonal disorders or adrenal dysfunction.