Cortisol, 24-Hour Urinary Free

Why This Test Is Done

Your doctor may recommend this test if they suspect conditions like Cushing’s syndrome (too much cortisol), adrenal insufficiency (too little cortisol), or chronic stress. It can also help diagnose or monitor certain hormonal disorders or evaluate how your body responds to stress or medications.

What to Expect Before the Test

You’ll collect your urine for 24 hours, starting and ending at the same time each day. Typically, you’ll empty your bladder at the start time, then collect all urine for the next 23 hours. Store the urine in a refrigerator or freezer until you return it to the lab. Follow your doctor’s specific instructions carefully to ensure accurate results.

What the Test Results Mean

Results are interpreted by your healthcare provider based on your medical history and symptoms. Elevated levels might indicate overproduction of cortisol, while lower levels could suggest adrenal problems or stress-related issues. No standard reference ranges are provided here—your doctor will compare your results to your unique health profile.

Common Conditions This Test Helps Diagnose

This test is often used to diagnose or monitor conditions such as Cushing’s syndrome, adrenal insufficiency (Addison’s disease), or to evaluate chronic stress responses. It can also help assess how well certain medications are affecting cortisol levels.