Total Serum Cortisol

Why Is This Test Done?

Your doctor may order this test to check for conditions like Cushing’s syndrome (too much cortisol), Addison’s disease (too little cortisol), or to evaluate how your body responds to stress or medications that affect cortisol levels. It can also help diagnose adrenal gland issues or monitor treatment progress.

What Does the Test Involve?

A blood sample is taken from a vein in your arm. You may feel a small pinch when the needle is inserted, but the procedure usually takes only a few minutes. No special preparation is typically needed, but your doctor may advise fasting or avoiding certain medications beforehand.

What to Expect After the Test

After the blood draw, you can return to your normal activities immediately. There may be mild bruising or soreness at the injection site, but this usually goes away quickly. If you experience excessive bleeding, swelling, or pain, contact your healthcare provider.

What Are Common Causes of Abnormal Results?

High cortisol levels might be linked to conditions like Cushing’s syndrome, prolonged stress, or certain medications. Low cortisol levels could indicate Addison’s disease, adrenal gland tumors, or long-term use of steroids. Your doctor will consider your symptoms and other test results to determine the cause.