Cortisol, Serum, Free (Mass Concentration)

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like unexplained weight changes, fatigue, or signs of adrenal gland issues (such as high or low blood pressure, muscle weakness, or mood changes). It could also be part of diagnosing conditions like Cushing’s syndrome or Addison’s disease, or to monitor treatment for hormone-related disorders.

What to Expect Before the Test

No special preparation is needed, but you may be asked to avoid certain medications (like steroids) that could affect cortisol levels. If you’re taking them, tell your provider. You’ll have a simple blood draw, usually from a vein in your arm.

What the Results Mean

Results are compared to reference ranges for healthy adults, but individual needs vary. High cortisol levels might suggest overproduction by the adrenal glands, while low levels could indicate adrenal insufficiency or other issues. Your provider will interpret results in the context of your symptoms and medical history.

Common Conditions This Test Helps Diagnose

This test is often used to diagnose or monitor conditions like Cushing’s syndrome (excess cortisol), Addison’s disease (adrenal insufficiency), or to evaluate stress responses in certain medical scenarios.