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Total IgE (Immunoglobulin E) Level

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Immunoglobulin E (IgE) in your blood. IgE is a type of antibody that plays a role in allergic reactions and responses to certain substances.

Quick summary

["IgE levels help identify allergies or immune system activity."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
61304-2
Short code
Cottonwood IgE/IgE total %
Synonyms
Cottonwood IgE/IgE total %
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms like sneezing, itching, skin rashes, or breathing difficulties that suggest allergies. It can also be used to monitor conditions like asthma, eczema, or chronic inflammatory diseases.

What to Expect During the Test

A small blood sample is taken from a vein, usually in your arm. The process is quick and typically done in a clinic or lab. No special preparation is needed, but you may want to avoid eating or drinking for a short time before the test if instructed by your provider.

How the Test Works

The blood sample is analyzed to measure the total IgE concentration. This is done using an immunoassay method, which detects the presence and amount of IgE antibodies in your blood.

Possible Results and Next Steps

Results may be compared to reference ranges to determine if your IgE levels are elevated or within normal limits. Elevated IgE levels often indicate allergies or other immune-related conditions. Your healthcare provider will discuss the results with you and may recommend further testing or treatments based on your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

IgE Total

Frequently asked questions

What Does an Elevated IgE Level Mean?
An elevated IgE level can signal an allergic reaction to specific substances like pollen, dust, or certain foods. It may also be associated with conditions such as asthma, hay fever, or other allergic disorders. Chronic high IgE levels could indicate conditions like atopic dermatitis or certain autoimmune diseases.
What Does a Normal IgE Level Indicate?
Normal IgE levels generally suggest a healthy immune response without significant allergic reactions or immune dysregulation. However, a normal range does not rule out allergies entirely, so symptoms and clinical evaluation are still important.
Can IgE Levels Change Over Time?
Yes, IgE levels can fluctuate depending on exposure to allergens, underlying health conditions, and treatments. Regular monitoring may be necessary for conditions like asthma or severe allergies to adjust management plans accordingly.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy