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Substance concentration of a specific analyte in serum/plasma (qualitative screening)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence or absence of a substance in your blood, often used to screen for certain conditions or exposures.

Quick summary

["This screening helps identify potential health concerns early."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
68329-2
Short code
COUNTRYOFORIGIN
Synonyms
—
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects the concentration of a particular substance in your blood, typically using a qualitative method. This means it tells you whether the substance is present or not, rather than providing a precise amount. The substance could relate to medications, toxins, or other compounds depending on the clinical context.

Why It Might Be Ordered

Your healthcare provider may order this test to check for exposure to harmful substances, monitor certain medications, or screen for conditions like drug abuse, poisoning, or metabolic disorders. It’s often used as a preliminary step before more detailed testing.

Sample Collection and Preparation

A blood sample is drawn from a vein in your arm. The blood is processed to separate the serum or plasma, which is then tested for the presence of the substance. This process is quick and typically done in a lab setting.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to avoid certain foods, medications, or activities for a short time before the test, depending on the reason for testing. Always follow your healthcare provider’s instructions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

A positive result may indicate exposure to a substance that could be harmful, such as toxins, drugs, or other chemicals. It can also help confirm the presence of certain medications or metabolic byproducts. A negative result means the substance was not detected in the sample, but further testing may still be needed to rule out other conditions.

Frequently asked questions

What Does a Positive or Negative Result Mean?
A positive result suggests the presence of the substance in your blood, which may require further evaluation by your healthcare provider to determine the cause and next steps. A negative result means the substance was not detected in this sample, but it doesn’t necessarily mean it’s not present in your body at other times or in other tissues.
Can This Test Be Used to Diagnose a Specific Condition?
This test is often used as a screening tool rather than a definitive diagnostic test. It may prompt additional testing to confirm a diagnosis or further investigate the cause of your symptoms.
How Often Should I Get This Test?
The frequency of this test depends on your medical condition, treatment plan, or exposure risk. Your healthcare provider will determine how often you need it based on your individual needs and circumstances.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy