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Serum or plasma concentration of a substance related to kidney function (e.g., creatinine, urea, or electrolytes measured in a 24-hour urine collection)

Published: August 9, 2026Updated: August 16, 2026

This test measures specific substances in your urine over a full day to help assess kidney function, fluid balance, or metabolic processes. It may also detect imbalances in electrolytes, waste products, or other chemicals in your body.

Quick summary

["Understanding how your body processes fluids, waste, and electrolytes over time can help identify kidney or metabolic issues early."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96546-7
Short code
Country where dx
Synonyms
Country where dx
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if they suspect kidney problems, fluid or electrolyte imbalances, or conditions affecting how your body handles waste (like diabetes or certain medications). It can also help monitor chronic conditions or guide treatment plans.

What to Expect Before the Test

You’ll need to collect all urine for 24 hours, starting and ending at the same time (e.g., midnight to midnight). Drink plenty of water to help your kidneys produce urine consistently. Avoid certain medications or foods that might interfere with results, if instructed.

What the Test Measures

This test typically checks for substances like creatinine, urea, sodium, potassium, or other electrolytes, proteins, or markers that reflect kidney function, hydration status, or metabolic health. Results help determine if your kidneys are working properly or if there’s an imbalance in your body’s chemistry.

How the Results Are Used

Your doctor will compare your results to standard ranges to identify any abnormalities. For example, high levels of certain substances might indicate kidney disease, dehydration, or other health concerns. Low levels could signal fluid overload or metabolic issues.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

24-Hour Urine Substance Profile (Qualitative/Quantitative)

Frequently asked questions

What could cause abnormal results?
Abnormal results may suggest kidney problems (like chronic kidney disease), fluid or electrolyte imbalances, diabetes, heart conditions, or certain medications/diseases that affect how your body processes waste. Always discuss results with your doctor for personalized interpretation.
How long will I need to wait for results?
Results typically take 1–3 business days, depending on your lab. Your doctor will contact you once they’re ready to review them with you.
Can I drink water before or during the 24-hour urine collection?
Yes, drink plenty of water throughout the day to ensure your urine volume is representative of your daily fluid intake. Avoid excessive caffeine or alcohol unless instructed otherwise, as they may affect results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy