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Paraprotein DNA Detection by Probe (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of DNA fragments from abnormal protein-producing cells (paraproteins) in your blood, often linked to conditions like multiple myeloma or plasma cell disorders.

Quick summary

["A screening tool to help identify potential blood disorders involving abnormal protein production."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
70024-5
Short code
C parap DNA Bld Ql NAA+probe
Synonyms
C parap DNA Bld Ql NAA+probe
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects DNA sequences from abnormal plasma cells, which may appear in your blood if you have conditions like multiple myeloma or other plasma cell disorders. This is done using a specialized DNA probe that binds to these fragments, allowing for qualitative detection.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like unexplained fatigue, bone pain, frequent infections, or if they suspect a plasma cell disorder based on other tests or symptoms.

Possible Preparations

No special preparation is needed for this test. You’ll provide a blood sample, usually drawn from a vein in your arm.

What to Expect After the Test

Results may take several days to weeks to be processed, depending on lab workflows. Follow-up with your healthcare provider to discuss results and next steps if needed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Positive results may indicate the presence of abnormal plasma cells, which can cause conditions like multiple myeloma or other plasma cell dyscrasias. These conditions can lead to symptoms like anemia, kidney problems, or increased infection risk. Further testing, such as bone marrow biopsy, may be needed to confirm diagnosis and guide treatment.

Short name

Paraprotein DNA Screening

Frequently asked questions

What does a positive result mean?
A positive result suggests the presence of DNA fragments from abnormal plasma cells, which may warrant further evaluation by your healthcare provider to determine if additional testing or monitoring is needed.
Can this test diagnose multiple myeloma?
No, this test is a screening tool. It may indicate a suspicion of plasma cell disorders but typically requires additional diagnostic tests, such as bone marrow biopsy, for a definitive diagnosis.
How often should I get this test?
Your healthcare provider will determine the frequency of testing based on your symptoms, medical history, and other test results. Follow their guidance for ongoing monitoring if applicable.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy