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C-peptide (Serum) – Quantitative

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of C-peptide, a small protein produced by your pancreas along with insulin during digestion. It helps assess how well your pancreas is producing insulin naturally.

Quick summary

["C-peptide helps diagnose and monitor diabetes and pancreatic function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
95076-6
Short code
C peptide 15M p meal SerPl-mCnc
Synonyms
C peptide 15M p meal SerPl-mCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85610
SNOMED
396252006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to check if your pancreas is making enough insulin naturally. It’s often used to diagnose type 1 diabetes, type 2 diabetes, or to evaluate how well insulin therapy is working. C-peptide levels can also help distinguish between insulin-dependent and insulin-independent diabetes.

How Is the Sample Collected?

A blood sample is taken from a vein, usually in your arm. You may feel a small pinch when the needle is inserted, but it typically only takes a few seconds. The blood is then sent to a lab for testing.

What Does the Test Result Mean?

Results are interpreted by your healthcare provider based on your medical history and symptoms. High levels may indicate healthy insulin production, while low levels could suggest diabetes or other pancreatic issues. No specific reference ranges are provided here, as they vary by lab and clinical context.

Common Reasons for Testing

Doctors may recommend this test if you have symptoms of diabetes, such as frequent urination, extreme thirst, unexplained weight loss, or fatigue. It’s also used in research or clinical settings to monitor insulin production in people with diabetes or those undergoing insulin therapy.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: serum

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

C-peptide testing is critical for diagnosing diabetes because it provides a more accurate picture of your body’s natural insulin production. Unlike insulin levels, which can be affected by recent insulin use, C-peptide reflects your pancreas’s ability to produce insulin independently. This helps doctors tailor treatment plans and avoid over- or under-medication.

Short name

C-peptide level

Frequently asked questions

What causes abnormal C-peptide levels?
Abnormally low C-peptide levels are often linked to diabetes (especially type 1) or conditions that impair insulin production, such as pancreatic diseases or autoimmune disorders. High levels may suggest normal insulin production or overproduction, though this is less common and usually requires further evaluation.
How long does it take to get results?
Test results typically arrive within 1–3 business days, depending on your lab’s processing time. Your doctor will contact you once they have the results to discuss them further.
Can I eat or drink before this test?
You may eat and drink normally before the test, as fasting is not required. However, always follow your doctor’s specific instructions, as some tests may have different guidelines.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy