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C-peptide (Serum/Plasma) with 1-Hour Postprandial Measurement

Published: August 9, 2026Updated: August 16, 2026

This test measures C-peptide, a natural byproduct of insulin production, taken from your blood after eating to help assess how your pancreas is managing glucose.

Quick summary

["Evaluates insulin production and glucose control after eating."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
57649-6
Short code
C peptide 1h pre chal SerPl-sCnc
Synonyms
C peptide 1h pre chal SerPl-sCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85610
SNOMED
396252006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have diabetes or are suspected of having insulin resistance, or if you need to monitor how your body processes food and blood sugar after meals. It can also help diagnose conditions like type 1 or type 2 diabetes or rule out other causes of high blood sugar.

What to Expect Before the Test

You’ll typically fast for a few hours before the test, but the 1-hour postprandial (after-eating) sample is collected shortly after you’ve eaten a meal. Bring any medications you’re taking and let your healthcare provider know about allergies or conditions that might affect results.

How the Test Works

A small blood sample is taken from a vein, usually in your arm. The sample is analyzed to measure C-peptide levels, which reflect insulin production. This test helps distinguish between insulin-dependent and insulin-independent glucose regulation.

What the Results Mean

Results help determine if your pancreas is producing insulin normally after meals. Abnormal levels may indicate issues like diabetes, pancreatic disease, or other metabolic disorders. Your doctor will interpret results in the context of your symptoms and medical history.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: serum

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

C-peptide 1h post-meal

Frequently asked questions

How often should I get this test?
This test is usually done once or twice at specific intervals, depending on your diagnosis or treatment plan. Follow your doctor’s recommendations for frequency, as it may vary for monitoring diabetes progression, insulin sensitivity, or other conditions.
Can I eat or drink anything before the 1-hour postprandial sample?
Yes, you should eat a standard meal as instructed by your healthcare provider. Avoid skipping meals or consuming unusual foods, as this may affect the test results.
Will this test show if I’m taking insulin?
No, C-peptide measures natural insulin production, not synthetic insulin. If you’re on insulin therapy, your doctor may use this test alongside others to assess your body’s own insulin response.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy