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C-peptide (Serum) with Mass Concentration Measurement

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of C-peptide, a small protein produced along with insulin in your pancreas. It helps assess how much insulin your body naturally makes.

Quick summary

["C-peptide helps doctors check insulin production and diagnose conditions like diabetes."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
47587-1
Short code
C peptide 1M p Glc SerPl-sCnc
Synonyms
C peptide 1M p Glc SerPl-sCnc
Category
glucose
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
true
Population
adult
Sex
all
Age range
18–65 years
CPT
85610
SNOMED
396252006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to evaluate your pancreas’s ability to produce insulin. It can help diagnose type 1 or type 2 diabetes, check for insulin resistance, or monitor treatment for conditions like diabetes or pancreatic issues. C-peptide levels can also help distinguish between insulin-dependent and insulin-independent diabetes.

What Does the Test Involve?

A blood sample is taken from a vein, usually in your arm. The sample is sent to a lab where it is analyzed to measure C-peptide concentration. No special preparation is needed, but fasting may be required depending on the clinical context.

What to Expect Before the Test

You may be asked to fast for a few hours before the test if it’s part of a glucose tolerance or insulin sensitivity study. Otherwise, you can eat and drink normally unless instructed otherwise. Wear comfortable clothing and bring any medications you’re currently taking.

What to Expect During the Test

The test involves a quick needle insertion to draw blood. You may feel a slight pinch, but it usually doesn’t cause discomfort. The process takes only a few minutes, and you can resume your normal activities afterward.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: serum

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

C-peptide levels are important because they reflect your natural insulin production. Low levels may indicate insufficient insulin production (e.g., type 1 diabetes), while high levels could suggest overproduction or resistance. Doctors use this test to confirm diabetes diagnosis, assess insulin deficiency, or evaluate treatment effectiveness in conditions like diabetes or pancreatic disorders.

Short name

C-peptide level

Frequently asked questions

What does a C-peptide test tell me about my diabetes?
A C-peptide test helps determine whether your diabetes is caused by insufficient insulin production (type 1 diabetes) or insulin resistance (type 2 diabetes). If your C-peptide levels are low, it suggests your body isn’t producing enough insulin naturally. If levels are high, it may indicate your body is producing insulin but not using it effectively.
How is C-peptide different from insulin?
C-peptide is a byproduct of insulin production. Unlike insulin, which is cleared quickly from the bloodstream, C-peptide stays in your system longer, providing a more stable measure of your pancreas’s insulin output. This makes C-peptide a better indicator of natural insulin production.
Can I eat or drink before this test?
Whether you can eat or drink depends on the reason for the test. If fasting is required (e.g., for glucose studies), follow your doctor’s instructions. Otherwise, you can eat and drink normally unless specified otherwise.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy