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C-peptide (Serum) Quantitative

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of C-peptide in your blood. C-peptide is a natural substance produced along with insulin when your pancreas releases it to manage blood sugar levels.

Quick summary

["C-peptide helps doctors assess how well your pancreas is producing insulin naturally."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58520-8
Short code
C peptide 5M p 1 mg Gc IV SerPl-sCnc
Synonyms
C peptide 5M p 1 mg Gc IV SerPl-sCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85610
SNOMED
396252006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is C-Peptide Used For?

C-peptide is primarily used to evaluate pancreatic function. It helps distinguish between conditions where insulin is produced naturally versus when it is injected or supplemented. For example, it can help identify whether diabetes is caused by insufficient insulin production (type 1 or type 2 diabetes) or other factors like insulin resistance or external insulin use.

Why Might You Need This Test?

Your doctor may order a C-peptide test if you have diabetes symptoms, unexplained blood sugar issues, or if they suspect a problem with how your pancreas produces insulin. It can also be used to monitor treatment effectiveness or rule out conditions like insulinoma (a rare tumor that causes excessive insulin production).

How Is the Test Done?

A blood sample is taken from a vein, usually in your arm. The sample is sent to a lab where it is analyzed to measure the concentration of C-peptide. This test does not require fasting, but your doctor may provide specific instructions.

What Does the Test Result Mean?

Results are interpreted based on your clinical picture rather than a single reference range. High levels may suggest overproduction of insulin (e.g., insulinoma) or recent insulin administration, while low levels may indicate insufficient pancreatic function. Your doctor will discuss findings in the context of your health.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: serum

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

C-peptide level

Frequently asked questions

How long does it take to get my C-peptide results back?
Results are typically available within 1–3 business days, depending on your lab. Follow-up with your healthcare provider to discuss the results and next steps.
Can I eat or drink before this test?
No fasting is required for this test. However, always follow your doctor’s specific instructions for preparation.
What are common reasons doctors order a C-peptide test?
Doctors may order it to diagnose or monitor diabetes, assess pancreatic function, or evaluate conditions like insulinoma or insulin resistance.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy