Skip to content

Protein Electrophoresis, Serum (Qualitative or Semi-Quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the different types of proteins in your blood, often used to check for conditions like multiple myeloma, kidney disease, or other protein abnormalities.

Quick summary

["Helps identify unusual protein patterns that may signal underlying health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
25569-5
Short code
C peptide sp11 p chal SerPl-sCnc
Synonyms
C peptide sp11 p chal SerPl-sCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85610
SNOMED
396252006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Proteins Are Being Tested?

Electrophoresis separates blood proteins based on size and electrical charge. Common bands include albumin, globulins (including immunoglobulins), and alpha/beta fractions. Abnormal bands or shifts may indicate conditions like multiple myeloma, liver/kidney disease, or infections.

Why Might This Test Be Ordered?

Your doctor may request this test if you have symptoms like unexplained weight loss, fatigue, swelling, or if they suspect conditions affecting protein production, such as kidney disease, liver disorders, or certain cancers.

How Is the Sample Collected?

A blood sample is drawn from a vein, typically in your arm. The serum (liquid part after clotting) is then analyzed in a lab.

What Are Common Findings?

Normal results show balanced protein bands. Abnormal findings may include extra bands (e.g., monoclonal spikes in multiple myeloma), low albumin, or high globulin levels, which can signal disease.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: serum

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test plays a key role in diagnosing and monitoring conditions like multiple myeloma, amyloidosis, or chronic kidney disease by revealing protein imbalances that aren’t detected by routine blood tests.

Short name

Protein Electrophoresis

Frequently asked questions

What does a ‘spike’ or extra band mean?
A spike or unusual band often suggests a monoclonal protein (e.g., from multiple myeloma) or other protein disorders. Your doctor will interpret results in context of your symptoms and medical history.
How often is this test repeated?
Frequency depends on your condition. For monitoring (e.g., myeloma), tests may be repeated every few months. For initial screening, it’s often done once unless symptoms persist.
Can diet affect protein electrophoresis results?
Dietary changes (e.g., high protein intake) may slightly alter protein levels, but electrophoresis focuses on qualitative patterns rather than absolute values. Avoid extreme diets before testing if advised by your doctor.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy