Skip to content

Protein Electrophoresis with Serum Protein Fraction Analysis (Qualitative or Semi-Quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the different types of proteins in your blood, including albumin, globulins, and other fractions, often used to assess liver function, kidney health, or protein disorders.

Quick summary

["This test helps identify imbalances in blood proteins that may signal underlying health issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58816-0
Short code
C peptide sp2 SerPl-mCnc
Synonyms
C peptide sp2 SerPl-mCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85610
SNOMED
396252006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test to diagnose or monitor conditions like liver disease, kidney disease, multiple myeloma, or other protein-related disorders. It can also help check for conditions affecting protein synthesis or breakdown in the body.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test if your provider specifies it. Bring any medications you’re taking to your appointment.

How the Test Is Performed

A blood sample is drawn from a vein, typically in your arm. The blood is then separated into components, including serum, which is analyzed using electrophoresis to separate proteins by size and charge.

What the Results Mean

Results show patterns of protein bands, which can indicate abnormal protein levels. For example, high levels of certain globulins might suggest inflammation or immune system issues, while low albumin could signal liver or kidney problems.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: serum

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Serum Protein Electrophoresis

Frequently asked questions

What causes abnormal protein patterns in this test?
Abnormal results may be linked to liver disease, kidney disease, infections, autoimmune conditions, or certain cancers. If you notice unexplained changes, discuss them with your provider.
How long does it take to get results?
Results are typically available within 24–48 hours, depending on lab processing times. Your provider will discuss them with you during a follow-up visit.
Can I eat or drink before this test?
Follow your provider’s instructions—some tests require fasting, while others do not. Always confirm with them before the appointment.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy