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Peptide C (Serum) by Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Peptide C, a small protein fragment produced during the breakdown of prothrombin in the blood. It helps assess liver function and blood clotting processes.

Quick summary

["Peptide C helps evaluate liver health and blood clotting risks."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
25576-0
Short code
C peptide sp3 p chal SerPl-sCnc
Synonyms
C peptide sp3 p chal SerPl-sCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85610
SNOMED
396252006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you have symptoms like jaundice, fatigue, or bleeding easily. It can also be used to monitor liver disease, liver transplant patients, or those with blood clotting disorders.

What Does a Result Mean?

Peptide C levels can vary based on liver function, clotting activity, and other health conditions. Abnormal results may indicate liver damage, clotting issues, or other metabolic problems.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is processed to separate serum (the liquid part after clotting). This serum is then tested for Peptide C levels using an immunoassay method.

Common Causes of Abnormal Results

Low levels may suggest liver disease, severe bleeding, or certain medications. High levels could indicate liver dysfunction or other conditions affecting blood clotting.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: serum

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Peptide C is a sensitive marker for prothrombin processing in the liver. It reflects the functional integrity of the liver’s clotting pathways and can be useful in diagnosing or monitoring liver disease, coagulopathy, or post-transplant complications.

Short name

Peptide C Level

Frequently asked questions

What does a Peptide C test measure?
It measures the concentration of Peptide C, a protein fragment produced during the natural breakdown of prothrombin in the blood, which helps assess liver function and blood clotting.
Can this test be affected by medications?
Yes, certain medications (like anticoagulants or liver-directed drugs) may influence Peptide C levels. Your doctor will consider these factors when interpreting results.
How soon will I get results?
Results are typically available within 24 to 48 hours, depending on lab processing times and your healthcare provider’s workflow.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy