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C-reactive protein, serum (high-sensitivity)

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that rises when inflammation is present, often used to check for signs of infection, injury, or other inflammatory conditions.

Quick summary

["hs-CRP helps track inflammation, aiding in early detection of conditions like heart disease or autoimmune disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
110993-3
Short code
C pneum IgG Msmt Ser
Synonyms
C pneum IgG Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to monitor chronic conditions like heart disease, arthritis, or to check for signs of infection, injury, or other inflammatory processes after surgery or trauma. It can also help assess how well treatments for inflammation are working.

What Does a High or Low Result Mean?

Elevated levels may indicate inflammation, infections, or conditions like rheumatoid arthritis or heart disease. Lower-than-normal results might suggest reduced inflammation, but they don’t always mean you’re healthy. Results depend on your overall health and medical history.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The blood is sent to a lab where it’s processed to separate serum. The test measures the protein using a sensitive method to detect even small amounts of inflammation.

What Are Common Causes of Abnormal Results?

High hs-CRP levels can be caused by infections, autoimmune diseases, heart problems, or recent injuries. Low levels may occur if inflammation is minimal, but they don’t rule out underlying issues. Other factors like age, diet, and medications can also affect results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: hs-CRP plays a key role in assessing long-term inflammation risk, guiding preventive care, and evaluating treatment responses in chronic diseases. It’s not a diagnostic test for specific conditions but helps monitor broader health trends.

Short name

hs-CRP

Frequently asked questions

What does a high hs-CRP level mean for my health?
A high hs-CRP level suggests increased inflammation in your body, which may raise the risk of certain conditions like heart disease or autoimmune disorders. Your doctor will consider this along with other test results and your medical history to make decisions about your care.
Can lifestyle changes affect hs-CRP levels?
Yes, lifestyle factors like diet, exercise, smoking, and stress can influence inflammation. Eating a heart-healthy diet, staying active, and avoiding smoking may help lower hs-CRP levels over time.
How often should I get this test?
Your doctor will determine how often you need this test based on your health needs. For example, people with heart disease or arthritis may get it more frequently to monitor inflammation. Follow your doctor’s recommendations.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy