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C-reactive protein (high-sensitivity) by turbidimetry (serum/plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that rises in response to inflammation, often used to assess low-grade inflammation or risk of cardiovascular events.

Quick summary

["hs-CRP helps track inflammation and may guide preventive care decisions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
6913-8
Short code
C pneum IgG Titr Ser IF
Synonyms
C pneum IgG Titr Ser IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
8
Ref high
61
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
CPT
82977
SNOMED
3110003
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is hs-CRP Used For?

hs-CRP is primarily used to evaluate systemic inflammation, monitor chronic conditions like arthritis or heart disease, or assess risk for future health issues such as heart attack or stroke. It’s not a diagnostic test for a single condition but often used alongside other tests.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The blood is processed to separate serum or plasma, then analyzed using a turbidimetric method to measure the protein concentration.

Why Might Your Doctor Order This Test?

Your doctor may order hs-CRP if you have symptoms of inflammation, a history of inflammatory diseases, or if you’re at higher risk for cardiovascular problems. It can also help monitor treatment effectiveness in certain conditions.

What Do Results Mean?

Results are reported in milligrams per liter (mg/L). Higher levels may indicate increased inflammation, while lower levels suggest reduced risk. Interpretation depends on clinical context and your overall health.

Reference range

Adult males: 8-61 U/L; Adult females: 5-36 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

hs-CRP

Frequently asked questions

Why do some people get repeated hs-CRP tests?
Repeated tests may be needed to monitor trends in inflammation over time, especially if you have chronic conditions like arthritis, heart disease, or other inflammatory disorders. Your doctor will use these results to adjust treatment plans.
Can lifestyle changes affect hs-CRP levels?
Yes, lifestyle factors such as diet, exercise, stress management, and smoking can influence inflammation levels. Small, sustainable changes—like eating a heart-healthy diet or quitting smoking—may help lower hs-CRP over time.
Is hs-CRP the same as a general C-reactive protein test?
No, hs-CRP (high-sensitivity) is more precise and detects lower levels of inflammation than standard C-reactive protein tests, making it useful for identifying subtle risks in some individuals.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy