Skip to content

Cerebrospinal Fluid (CSF) Protein Measurement by Turbidimetry

Published: August 9, 2026Updated: August 16, 2026

This test measures the total protein content in your cerebrospinal fluid (the fluid surrounding your brain and spinal cord). It helps assess conditions affecting the brain and spinal cord, such as infections, inflammation, or bleeding.

Quick summary

["Protein levels in CSF can signal underlying neurological issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109465-5
Short code
C pneum IgM Msmt CSF
Synonyms
C pneum IgM Msmt CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like headaches, neck stiffness, confusion, or signs of infection (e.g., fever, nausea). It’s also used to diagnose conditions like meningitis, multiple sclerosis, or tumors in the central nervous system.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your back to collect a sample of CSF, often done while lying on your side. The procedure is quick but may cause mild discomfort.

What the Results Mean

Normal protein levels in CSF are generally lower than in blood. Elevated levels can indicate inflammation, infection, or other neurological issues. Very low levels may suggest certain blood disorders or bleeding in the brain.

Common Conditions Affecting Results

High protein levels might be seen in conditions like meningitis, multiple sclerosis, or brain tumors. Low protein levels could be linked to bleeding in the brain or certain blood diseases.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is critical for diagnosing and monitoring neurological disorders, guiding treatment decisions, and ruling out serious conditions like infections or tumors in the brain or spinal cord.

Short name

CSF Protein

Frequently asked questions

Will I feel pain during the test?
You may feel a mild pinch or discomfort during the needle insertion, but it usually doesn’t cause significant pain. Some people report a slight ache afterward.
How long will it take to get my results?
Results are typically available within a few days, depending on lab processing times. Your doctor will discuss them with you during your follow-up visit.
Can I drink or eat before this test?
No restrictions apply. You can eat, drink, or take medications as usual unless your doctor advises otherwise.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy