Cerebrospinal Fluid Protein by Turbidimetry (Total Protein)
This test measures the total protein content in your cerebrospinal fluid (CSF), which is the clear fluid surrounding your brain and spinal cord. Protein levels can help diagnose conditions affecting the central nervous system.
["Protein in CSF may signal inflammation, infection, or structural issues in the brain or spinal cord."]
Key facts at a glance
- LOINC
- 16583-7
- Short code
- C pneum IgM Titr CSF IF
- Synonyms
- C pneum IgM Titr CSF IF
- Category
- chemistry
- Sample
- csf
- Container
- Sterile tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- if
- CPT
- 82784
- Specimen volume
- 1-2 mL
- Stability
- Immediate analysis required, Refrigerated: 1h
- Hemolysis max
- 200
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your doctor may order this test if you have symptoms like headaches, neck stiffness, vision changes, or neurological issues that could indicate conditions such as meningitis, multiple sclerosis, or other brain/spinal cord disorders. It’s also used to monitor treatment progress or investigate unexplained neurological symptoms.
What to Expect Before the Test
You’ll likely have a lumbar puncture (spinal tap) where a small needle is inserted into your lower back to collect CSF. The procedure is quick but may cause mild discomfort. No special preparation is needed, but inform your doctor about any medications or allergies.
What the Results Mean
Protein levels in CSF can vary based on health, age, and medical conditions. High protein levels may suggest inflammation, infection, or blood leakage into the CSF. Low levels are less common but could indicate certain neurological disorders. Your doctor will interpret results in the context of your symptoms and medical history.
Common Conditions Affecting Results
Elevated protein levels are often seen in conditions like meningitis, encephalitis, or multiple sclerosis. Increased protein can also occur with tumors, trauma, or autoimmune diseases affecting the central nervous system. Low protein levels are rare but may be linked to specific genetic or metabolic disorders.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
CSF Protein Level
Frequently asked questions
Will I need to fast before this test?
What if my protein levels are outside the normal range?
Can I drink fluids before the procedure?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy