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Nucleic Acid Detection for *SARS-CoV-2* (COVID-19) by Qualitative Probe Amplification

Published: August 9, 2026Updated: August 16, 2026

This test checks for the genetic material of the virus that causes COVID-19 in a sample taken from your nose or throat. It helps determine if you have an active infection.

Quick summary

["This test helps diagnose COVID-19 by detecting the virus’s genetic material."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
24402-0
Short code
C pn+psitt DNA Spec Ql Probe amp
Synonyms
C pn+psitt DNA Spec Ql Probe amp
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

How the Test Works

The test uses a special probe to detect the virus’s genetic material (nucleic acids) in a sample collected from your upper respiratory tract. This process involves amplification to make the genetic material detectable, often through a molecular method like PCR (Polymerase Chain Reaction).

Sample Collection

A swab is inserted into your nose or throat to collect a sample. This is usually done by a healthcare provider or nurse. The sample is then sent to a lab for testing.

When You Might Need This Test

You may need this test if you have symptoms of COVID-19 (such as fever, cough, or shortness of breath), have been exposed to someone with COVID-19, or are required to test as part of travel, workplace, or school protocols.

What to Expect During Testing

The test itself is quick and painless. You may feel mild discomfort from the swab, but it usually takes only a few minutes. Results can take several hours to a few days, depending on lab processing times.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

COVID-19 Nucleic Acid Test

Frequently asked questions

What does a positive result mean?
A positive result means the test detected the virus’s genetic material in your sample, indicating you likely have an active COVID-19 infection. Follow your healthcare provider’s guidance on next steps, such as isolation or treatment.
What does a negative result mean?
A negative result means the test did not detect the virus’s genetic material in your sample at the time of testing. However, it’s possible you could still be infected if the test was taken too early in your illness. Retesting may be recommended if symptoms persist or worsen.
How accurate is this test?
This test is highly accurate when performed correctly, but like all tests, it can have false negatives or false positives. Results should be interpreted by a healthcare provider in the context of your symptoms, medical history, and other factors.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy