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C-reactive protein (high-sensitivity) concentration

Published: August 9, 2026Updated: August 17, 2026

This test measures a protein in your blood that rises in response to inflammation, helping doctors assess low-level inflammation or risk of conditions like heart disease.

Quick summary

["hs-CRP helps track subtle inflammation, often used alongside other tests for heart health or autoimmune monitoring."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
102005-6
Short code
Cr IgE RAST
Synonyms
Cr IgE RAST
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
40
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
rast
CPT
84484
SNOMED
302774002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is hs-CRP Used For?

hs-CRP (high-sensitivity C-reactive protein) is typically ordered to evaluate the risk of cardiovascular events, such as heart attacks or strokes, especially in people with no obvious symptoms of inflammation. It may also help monitor chronic conditions like rheumatoid arthritis or other inflammatory diseases.

How Is the Test Performed?

A small blood sample is drawn from a vein, usually in your arm. The blood is sent to a lab where it is analyzed using a sensitive immunoassay method to detect even small amounts of the protein.

What Does a High or Low Result Mean?

Results are not given in absolute numbers but are interpreted in the context of your overall health. Higher levels may indicate increased inflammation or risk for heart disease, while lower levels suggest reduced inflammation. Your doctor will discuss these findings with you.

What Can Affect Results?

Factors like recent infection, injury, stress, or certain medications (e.g., steroids) can temporarily raise hs-CRP levels. Avoiding vigorous exercise or exposure to infections before testing may help get more accurate results.

Reference range

Adult: 10-40 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

hs-CRP

Frequently asked questions

Why might my doctor order this test?
Your doctor may order hs-CRP to assess your risk for heart disease, especially if you have risk factors like high blood pressure, diabetes, or a family history of heart problems. It can also help monitor conditions like rheumatoid arthritis or other inflammatory diseases.
What does an abnormal result mean?
An abnormal result doesn’t diagnose a specific condition alone but may signal increased inflammation or risk. Your doctor will review the result alongside other tests and your medical history to guide further action.
Can lifestyle changes affect hs-CRP levels?
Yes, lifestyle changes such as improving diet, increasing physical activity, managing stress, and quitting smoking can help lower inflammation and potentially reduce hs-CRP levels over time.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy