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Cryoglobulin profile (mass concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of cryoglobulins in your blood, which are proteins that can clump together and form deposits when the blood cools. Cryoglobulins are often associated with certain autoimmune conditions.

Quick summary

["Cryoglobulins can cause symptoms like fatigue, swelling, or skin changes when they form in your bloodstream."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
2166-7
Short code
Cryoglob Bld-mCnc
Synonyms
Cryoglob Bld-mCnc
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Is a Cryoglobulin Profile Used For?

A cryoglobulin profile helps doctors diagnose conditions like mixed cryoglobulinemia, which is linked to autoimmune diseases such as lupus, rheumatoid arthritis, or hepatitis C. It may also be used to monitor treatment progress or identify complications in patients with these conditions.

How Is the Test Performed?

Blood is drawn from a vein in your arm. The sample is then tested to detect and measure the concentration of cryoglobulins, which may appear as clumps when the blood is cooled.

What Are Common Symptoms Cryoglobulin Levels Might Relate To?

High levels of cryoglobulins can cause symptoms such as cold sensitivity, skin rashes, joint pain, or swelling in hands and feet. These symptoms often worsen when the blood cools.

How Might Results Affect My Treatment?

If your test results show abnormal cryoglobulin levels, your healthcare provider may recommend further testing or treatments to manage your condition, such as medications to reduce inflammation or address the underlying autoimmune or infectious cause.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cryoglobulin Levels

Frequently asked questions

Why might my doctor order a cryoglobulin profile test?
Your doctor may order this test if you have symptoms like joint pain, skin rashes, or unexplained fatigue, especially if you have a history of autoimmune diseases (e.g., lupus, rheumatoid arthritis) or infections (e.g., hepatitis C).
What does it mean if my cryoglobulin levels are high?
High levels may indicate mixed cryoglobulinemia, an autoimmune condition that can cause symptoms like swelling, skin ulcers, or nerve damage. Your doctor will discuss next steps, such as further testing or treatment options.
Can cryoglobulins be treated?
Yes, treatments may include medications to reduce inflammation, manage autoimmune activity, or address infections like hepatitis C. Lifestyle changes, such as avoiding cold exposure, may also help manage symptoms.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy