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Cryoglobulin Profile (Cryoglobulins, Fibrin Degradation Products)

Published: August 9, 2026Updated: August 16, 2026

This test measures two related proteins in your blood: cryoglobulins (abnormal proteins that form clumps when cooled) and fibrin degradation products (byproducts of blood clot breakdown).

Quick summary

["Helps diagnose conditions linked to abnormal blood clotting or immune system activity."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
74352-6
Short code
Cryoglob+cryofib Pnl Ser+Pl
Synonyms
Cryoglob+cryofib Pnl Ser+Pl
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like fatigue, joint pain, or unexplained bruising, or if you have conditions such as lupus, hepatitis, or certain cancers. It may also be used to monitor treatment progress for conditions affecting blood clotting or immune function.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into a vein (usually in your arm) to draw blood. The process is quick and typically causes only mild discomfort.

What the Test Measures

The test detects two components: cryoglobulins (which may indicate immune system disorders) and fibrin degradation products (which signal recent or ongoing blood clot activity).

Possible Conditions Linked to Results

High levels of cryoglobulins or fibrin degradation products may suggest autoimmune diseases, infections, or conditions like vasculitis or certain cancers. Low or normal levels usually indicate no immediate concern.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cryo/Fibrin Profile

Frequently asked questions

What does a positive result mean?
A positive result (elevated levels) may indicate an immune system disorder, infection, or blood clot activity. Your doctor will discuss next steps based on your symptoms and overall health.
Can diet or lifestyle changes affect these test results?
Diet or lifestyle changes may not directly influence cryoglobulin or fibrin degradation product levels, but managing conditions like diabetes or infections can indirectly support better test outcomes.
How soon will I get my results?
Results are typically available within 1–3 business days, depending on lab processing times. Your healthcare provider will contact you to discuss them.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy