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Cryoglobulin Profile (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test checks for abnormal proteins called cryoglobulins in your blood that may form clumps when cooled, potentially causing symptoms like fatigue or swelling.

Quick summary

["A cryoglobulin screen helps identify conditions linked to immune system dysfunction or infections."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
55846-0
Short code
Cryoglob IgA moncl Ser Ql
Synonyms
Cryoglob IgA moncl Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Are Cryoglobulins?

Cryoglobulins are abnormal proteins in your blood that can solidify (precipitate) when exposed to lower temperatures. They may be part of a broader immune-related condition or a reaction to certain infections.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms like joint pain, skin rashes, fatigue, or signs of an infection. It’s also used to monitor conditions like chronic hepatitis or certain autoimmune diseases.

How Is the Test Performed?

A blood sample is drawn, and the serum/plasma is tested for cryoglobulin presence by observing how it behaves when cooled. The result is qualitative (positive/negative) rather than a numeric value.

What Are Possible Results?

A positive result means cryoglobulins were detected, which may indicate an underlying immune issue or infection. A negative result means no abnormal proteins were found in this sample.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cryoglobulin Screen

Frequently asked questions

What does a positive cryoglobulin screen mean?
A positive result suggests you may have an immune-related condition or an infection that affects your blood proteins. Your doctor will likely recommend further testing or monitoring to determine the cause and next steps.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times. Follow-up with your healthcare provider for interpretation.
Can lifestyle changes help if I have cryoglobulins?
While lifestyle adjustments (like managing infections or reducing stress) may support overall health, they won’t directly treat cryoglobulin-related conditions. Work with your doctor for personalized advice.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy