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Serum Cryoglobulins (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test checks for abnormal proteins called cryoglobulins in your blood that may form clumps when cooled, potentially causing symptoms like fatigue, swelling, or skin changes.

Quick summary

["Cryoglobulins can signal conditions like infections, autoimmune diseases, or certain cancers—early detection helps guide treatment."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
110838-0
Short code
Cryoglob IgA Msmt Ser
Synonyms
Cryoglob IgA Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Are Cryoglobulins?

Cryoglobulins are proteins in your blood that can solidify (precipitate) when exposed to cold temperatures. They may be normal in small amounts but can become harmful if present in excess or mixed with other abnormal proteins.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms like joint pain, skin rashes, fever, or signs of an infection. It’s also used to monitor conditions like chronic hepatitis or autoimmune diseases.

How Is the Test Performed?

A blood sample is drawn, and your serum is tested for abnormal protein patterns that form clumps when cooled. Results are qualitative (positive/negative) rather than a numeric value.

What Do Results Mean?

Positive results suggest abnormal proteins may be causing issues, but further testing (like confirmatory assays) is needed to identify the exact cause. Negative results mean no obvious clumping proteins were detected.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cryoglobulin Screen

Frequently asked questions

What causes cryoglobulins to appear in my blood?
Cryoglobulins can form due to infections (like hepatitis), autoimmune diseases, or rare blood disorders. Your doctor will discuss possible causes based on your symptoms and medical history.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times. Follow-up with your doctor is needed for interpretation.
Can I take anything special before this test?
No special preparations are needed, but avoid alcohol 24 hours before testing if your doctor advises it, as it may affect protein levels.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy