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Cryoglobulin Profile (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence and type of cryoglobulins—abnormal proteins in your blood that can clump together when the blood cools. These proteins may be linked to certain autoimmune conditions or infections.

Quick summary

["Cryoglobulins can cause symptoms like fatigue, swelling, or skin changes and may require further evaluation if detected."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
15171-2
Short code
Cryoglob IgA Ser-aCnc
Synonyms
Cryoglob IgA Ser-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Are Cryoglobulins?

Cryoglobulins are abnormal proteins found in your blood that can form visible clumps (precipitates) when the blood temperature drops below body temperature. These proteins are often associated with immune system disorders or infections.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms like joint pain, skin rashes, swelling, or unexplained fatigue. It can also help diagnose conditions such as vasculitis, chronic infections (like hepatitis), or certain autoimmune diseases.

How Is the Test Performed?

A small blood sample is drawn from a vein in your arm. The blood is then cooled to detect any clumping of cryoglobulins. If clumps form, they are analyzed further to determine their type (monoclonal, mixed, or polyclonal).

What Does the Test Result Mean?

Results may show elevated or abnormal levels of cryoglobulins, which can indicate an underlying condition. A positive test alone doesn’t diagnose a specific disease but may prompt additional testing for conditions like vasculitis or chronic infections.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cryoglobulin Levels

Frequently asked questions

What causes cryoglobulins to appear in the blood?
Cryoglobulins can appear due to autoimmune disorders (like rheumatoid arthritis), chronic infections (such as hepatitis B or C), or certain cancers (like lymphoma). Stress, medications, or other health conditions may also contribute.
How long does it take to get results from this test?
Results are typically available within 1–3 business days, depending on lab processing times. Your doctor will discuss the findings with you during your follow-up visit.
Can lifestyle changes help manage cryoglobulin-related symptoms?
While lifestyle adjustments like staying hydrated, managing stress, and avoiding extreme cold may help ease symptoms, treatment often focuses on addressing the underlying cause, such as medications or infection control.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy