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Cold-Sensitive Cryoglobulin Profile (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures proteins in your blood that may thicken and form clumps when exposed to cold. These clumps, called cryoglobulins, can sometimes cause health problems.

Quick summary

["Cold-sensitive cryoglobulins may indicate underlying conditions like infections, autoimmune diseases, or liver disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
40580-3
Short code
Cryoglob IgA Ser Cold-mCnc
Synonyms
Cryoglob IgA Ser Cold-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
cold-incubation
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is a Cryoglobulin?

Cryoglobulins are abnormal proteins in your blood that become sticky and form visible clumps when the blood cools down. These clumps can block small blood vessels, leading to symptoms like fatigue, swelling, or skin changes.

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms like unexplained fevers, joint pain, skin rashes, or signs of organ damage. It’s also used to monitor conditions like lupus, hepatitis, or infections that can cause cryoglobulins.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The blood is then tested in a lab to detect the presence of cold-sensitive proteins that form clumps when cooled.

What Are Possible Results?

Results may show elevated levels of cryoglobulins, which could suggest an underlying condition. However, normal results don’t definitively rule out all causes of symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cryoglobulin Screen

Frequently asked questions

What does a positive cryoglobulin test mean?
A positive result means your blood contains proteins that thicken in cold temperatures. This may indicate an immune system issue, infection, or other health concerns that require further evaluation by your doctor.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on your lab’s processing time. Your healthcare provider will discuss the findings with you.
Can lifestyle changes help if I have elevated cryoglobulins?
While lifestyle changes like avoiding cold exposure or managing chronic conditions (e.g., infections, diabetes) may help, treatment often requires medical intervention, such as medications to control immune activity or infections.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy