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Cryoglobulin (Immunoassay) Profile

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence and type of cryoglobulins—abnormal proteins in your blood that may clump together when cooled, potentially causing health issues like inflammation or blood flow problems.

Quick summary

["Cryoglobulins can signal underlying conditions that may need medical attention."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
40628-0
Short code
Cryoglob IgA Ser Inc-mCnc
Synonyms
Cryoglob IgA Ser Inc-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
deg-c-incubation
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Are Cryoglobulins?

Cryoglobulins are abnormal proteins found in your blood that can form clumps when exposed to cooler temperatures. These clumps may block small blood vessels, leading to symptoms like swelling, pain, or skin changes. They can also be linked to immune system disorders or infections.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms like joint pain, skin rashes, fatigue, or unexplained fevers, or if they suspect conditions like cryoglobulinemia, lupus, hepatitis, or other autoimmune diseases.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The blood is then analyzed in a lab using an immunoassay method to detect and measure cryoglobulins.

What Do Results Mean?

Results may show elevated or abnormal levels of cryoglobulins, which could indicate an underlying condition requiring further evaluation. Normal results suggest no significant clumping proteins in your blood.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Cryoglobulins can indicate conditions such as mixed cryoglobulinemia (often linked to hepatitis C or autoimmune disorders), immune complex diseases, or other inflammatory or infectious processes. Early detection helps guide treatment and management strategies.

Short name

Cryoglobulin Levels

Frequently asked questions

What causes cryoglobulins to form?
Cryoglobulins can form due to immune system dysfunction, infections (like hepatitis C), or autoimmune diseases. Stress, certain medications, or genetic factors may also play a role.
How long does it take to get results?
Results are typically available within 1 to 3 business days, depending on lab processing times.
Can lifestyle changes help manage cryoglobulinemia?
While lifestyle changes like managing infections, reducing stress, and following prescribed treatments (e.g., medications for inflammation) may help, this test is primarily diagnostic and not a standalone treatment.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy