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Serum Cryoglobulin Profile (Electrophoresis)

Published: August 9, 2026Updated: August 16, 2026

This test measures proteins called cryoglobulins in your blood, which may form clumps when cooled. These clumps can cause symptoms like fatigue, swelling, or skin changes.

Quick summary

["Cryoglobulins may indicate underlying conditions like infections, autoimmune diseases, or certain cancers."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
81311-3
Short code
Cryoglob IgA Ser Ql
Synonyms
Cryoglob IgA Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Are Cryoglobulins?

Cryoglobulins are abnormal proteins in your blood that can clump together when exposed to lower temperatures. These clumps can block small blood vessels, leading to symptoms like pain, swelling, or skin rashes. They can also cause damage to organs over time.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms like joint pain, skin ulcers, or unexplained fatigue, or if you have conditions like hepatitis, lupus, or certain infections that can trigger cryoglobulin production.

What to Expect During the Test

A blood sample will be drawn from a vein in your arm. The blood is then processed and analyzed using electrophoresis to separate and identify cryoglobulins. Results help determine if clumping is present and its potential impact on your health.

Common Conditions Linked to Cryoglobulins

High levels of cryoglobulins are often associated with autoimmune diseases (such as mixed cryoglobulinemia), chronic infections (like hepatitis C), or certain cancers. They may also appear in people with no obvious disease but with unexplained symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cryoglobulin Screen/Confirm

Frequently asked questions

What does a positive cryoglobulin test mean?
A positive test means cryoglobulins are present in your blood, which may indicate an underlying condition requiring further evaluation. Your doctor will discuss next steps based on your symptoms and test results.
How are cryoglobulins treated?
Treatment depends on the cause. If due to an infection (e.g., hepatitis C), antiviral therapy may be recommended. For autoimmune conditions, medications to reduce inflammation or immune activity may be used. Lifestyle changes or monitoring may also be part of the plan.
Can cryoglobulins be prevented?
Prevention is often tied to managing underlying conditions. Treating infections promptly, controlling autoimmune activity, and following medical advice can help reduce cryoglobulin levels and symptoms.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy