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Cryoglobulins (Screening)

Published: August 9, 2026Updated: August 16, 2026

This test measures proteins in your blood that may form clumps (cryoglobulins) when cooled, which can cause symptoms like fatigue, joint pain, or swelling.

Quick summary

["This screening helps identify potential blood disorders linked to cold-sensitive proteins."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
55847-8
Short code
Cryoglob IgG moncl Ser Ql
Synonyms
Cryoglob IgG moncl Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like unexplained fatigue, joint pain, or swelling, or if you have conditions like lupus, rheumatoid arthritis, or infections that can trigger cryoglobulin production.

What to Expect During the Test

A blood sample is drawn from a vein in your arm. The sample is sent to a lab where it’s analyzed for cryoglobulins using electrophoresis, a method that separates proteins based on size and charge.

What the Results Mean

Positive results suggest the presence of abnormal proteins that may clump in cold temperatures. Further testing (like confirmation via nephelometry) may be needed to determine if these proteins are causing symptoms.

Common Conditions Linked to Cryoglobulins

Cryoglobulins are often linked to autoimmune diseases (e.g., mixed cryoglobulinemia), infections (e.g., hepatitis C), or other inflammatory conditions. They can block blood flow, leading to organ damage if untreated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CryoScreen

Frequently asked questions

What causes cryoglobulins to appear in my blood?
Cryoglobulins are often produced by the immune system in response to infections (like hepatitis C), autoimmune diseases, or certain medications. Stress, cold exposure, or genetic factors may also play a role.
Do I need to prepare for this test?
No special preparation is needed. However, avoid taking blood-thinning medications (like aspirin) 24 hours before testing if your doctor advises it.
Can cryoglobulins be treated?
Yes, treatment depends on the underlying cause. For infections, antibiotics may help. Autoimmune conditions may require immunosuppressants or other therapies to reduce protein production.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy