Cryoglobulins (Serum)
This test measures proteins in your blood that can thicken and form clumps when cooled, called cryoglobulins. These may indicate an underlying immune system issue.
["Cryoglobulins can signal conditions needing further medical evaluation."]
Key facts at a glance
- LOINC
- 15172-0
- Short code
- Cryoglob IgG Ser-aCnc
- Synonyms
- Cryoglob IgG Ser-aCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Is a Cryoglobulin Screen Used For?
Doctors may order this test to investigate symptoms like fatigue, joint pain, or skin changes that could be linked to immune-related disorders. It can also help diagnose conditions such as vasculitis or certain infections that affect blood flow and tissue health.
How Is the Test Performed?
A blood sample is drawn from a vein, usually in your arm. The sample is then tested in a lab to detect abnormal proteins that form clumps when exposed to cooler temperatures.
What Are Common Symptoms to Report Before Testing?
Inform your healthcare provider if you have recent infections, unexplained fevers, rash, or persistent swelling in limbs. These symptoms may affect test results or require additional testing.
What Does a Positive Result Mean?
A positive result suggests the presence of cryoglobulins, which may indicate conditions like mixed cryoglobulinemia, autoimmune diseases, or chronic infections. Further testing, such as confirmatory assays or additional bloodwork, may be needed to determine the cause.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Cryoglobulins can block small blood vessels, causing pain, swelling, or organ damage. Early detection helps guide treatment to manage symptoms and prevent complications, such as nerve damage or kidney issues.
Short name
Cryoglobulin Screen
Frequently asked questions
Why might my doctor order this test?
What does it mean if my cryoglobulin levels are elevated?
Can lifestyle changes affect cryoglobulin test results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy