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Cryoglobulin (Serum) Cold Dilution Test

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of abnormal proteins called cryoglobulins in your blood that become thicker or solidify when exposed to cold temperatures.

Quick summary

["Helps identify potential blood disorders linked to cold sensitivity in proteins."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
40579-5
Short code
Cryoglob IgG Ser Cold-mCnc
Synonyms
Cryoglob IgG Ser Cold-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
cold-incubation
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is a Cryoglobulin Test Used For?

Cryoglobulins are proteins found in your blood that can clump together when the temperature drops. This test checks for these proteins, which may indicate conditions like chronic infections, autoimmune diseases, or certain cancers. It’s often used to diagnose or monitor conditions such as vasculitis, lymphoma, or hepatitis-related disorders.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms like cold sensitivity, skin rashes, joint pain, or unexplained fatigue. It can also be part of evaluating blood vessel inflammation or detecting abnormal protein buildup in your bloodstream.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The sample is then placed in a cold environment to see if the cryoglobulins clump. The lab analyzes whether these clumps form and their characteristics.

What Are Common Results?

Results are qualitative (positive or negative) rather than numerical. A positive test means cryoglobulins were detected, which may require further testing to determine the underlying cause.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cryoglobulin Test

Frequently asked questions

What Does a Positive Result Mean?
A positive result suggests abnormal proteins may be affecting your blood vessels or causing symptoms like fatigue, skin changes, or organ damage. Your doctor will likely recommend additional tests to identify the root cause.
How Often Should I Get This Test?
Frequency depends on your symptoms and medical history. Your doctor may repeat it if you have ongoing concerns about cold sensitivity, unexplained rashes, or other related symptoms.
Can Diet or Lifestyle Affect This Test?
Diet or lifestyle changes alone won’t alter the test results, but managing conditions like infections or autoimmune diseases may influence your overall health and need for follow-up testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy