Cryoglobulins (Serum)
This test measures the presence and type of proteins called cryoglobulins in your blood. Cryoglobulins are abnormal proteins that can form clumps (precipitates) when the blood cools, which may cause symptoms or complications.
["Cryoglobulins can signal underlying conditions that may affect circulation or immune function."]
Key facts at a glance
- LOINC
- 40582-9
- Short code
- Cryoglob IgG Ser Inc-mCnc
- Synonyms
- Cryoglob IgG Ser Inc-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- deg-c-incubation
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Are Cryoglobulins?
Cryoglobulins are abnormal proteins found in your blood that can clump together when exposed to cold temperatures. These clumps can block small blood vessels, potentially leading to symptoms like pain, swelling, or skin changes. They may also indicate an overactive immune system or other health conditions.
Why Might You Need This Test?
Your healthcare provider may order this test if you have symptoms such as cold sensitivity, skin rashes, joint pain, fatigue, or signs of circulation issues. It’s also used to diagnose or monitor conditions like lupus, infections, or certain cancers that may produce cryoglobulins.
Common Causes and Conditions
Cryoglobulins are often linked to conditions such as chronic infections (e.g., hepatitis C), autoimmune diseases (e.g., rheumatoid arthritis), or lymphoproliferative disorders. In some cases, they may appear without an obvious cause.
What to Expect During the Test
A blood sample will be drawn from a vein in your arm. The blood is then processed to detect cryoglobulins. Results are typically reported as qualitative (positive/negative) or quantitative (concentration levels), depending on the clinical context.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Cryoglobulin Profile
Frequently asked questions
Cryoglobulins can indicate serious conditions that require medical attention. High levels may cause tissue damage, organ dysfunction, or worsening of symptoms like neuropathy or skin ulcers. Early diagnosis helps guide treatment, such as managing infections, controlling autoimmune activity, or addressing underlying cancers.
Results may take several days to a few weeks, depending on the lab’s processing schedule and follow-up needs. Your healthcare provider will discuss the timing with you before ordering the test.
A positive result suggests the presence of cryoglobulins, which may point to an underlying condition. Your doctor will interpret the results in the context of your symptoms and medical history to determine next steps, such as further testing or treatment.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy